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1 Estimation of the Number of Early Physical and Biochemical Changes That Occur When Mammalian Cells Are Irradiated with 1 Gy of Low LET Radiation Initial Physical Damage Ionization in the cell nucleus 1000,000 Ionization directly in DNA 2000 Excitation directly in DNA 2000 Selected Biochemical Damage Damaged bases 10002000 Damaged sugars 1200 DNA single-strand breaks (SSBs) 1000 Alkali-labile sites 250 Double-strand breaks (DSBs) 40 DNA-protein cross-links (DPC) 150 Selected Cellular Effects Lethal events 0.Sonenberg, N.

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