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Transfusion 1978;18:375. 2 Reactions of the Citric Acid Cycle 607 CH3 C S-CoA citrate synthase 8 Dehydrogenation COO fumarase COO CH HC COO 6 O C COO CH2 COO Oxaloacetate malate dehydrogenase Citric acid cycle NADH CH2 COO Citrate aconitase 2a Dehydration H2O HO Malate CH2 CH2 COO C COO C COO H aconitase CH COO cis-Aconitate H2O 2b Hydration 7 Hydration H2O Fumarate CH2 COO H C COO FADH2 succinate dehydrogenase CH2 COO CH HO C H Isocitrate 3 Oxidative depository receipts trading COO Dehydrogenation isocitrate dehydrogenase CH2 COO CH2 C O COO -Ketoglutarate CO2 2 succinyl-CoA synthetase -ketoglutarate dehydrogenase complex CoA-SH CO2 COO Succinate CoA-SH GTP (ATP) CH2 COO CH2 C S -CoA GDP O (ADP) Succinyl-CoA Pi 54 Substrate-level phosphorylation FIGURE 167 Reactions of the citric acid cycle.

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