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TURNLUND Historical Periof Chemistry Causes and Manifestations of Deficiency Requirements and Recommended Intakes Causes and Manifestations of Toxicity Dietary Considerations Food Sources Bioavailability Interactions Adequacy of Intake by Various Population Groups Metabolism Absorption Storage Transport Excretion Homeostatic Regulation Functions Biochemical Physiologic Copper Deficiency in Animals Copper Deficiency in Humans Clinical Conditions Clinical Conditions with Increased Risk of Copper Depletion Clinical Conditions Accompanied by Copper Accumulation Conditions with Increased Serum Copper Genetic Defects in Copper Metabolism Evaluation of Copper Status Laboratory Animals Humans Copper Toxicity in Animals Copper Toxicity in Humans Chapter References Selected Readings HISTORICAL INTRODUCTION Copper has been used therapeutically since at least 400 BC, when Hippocrates prescribed copper compounds for pulmonary and other diseases ( 1).
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